VIP 5MG

VIP (Vasoactive Intestinal Peptide)

VIP is a 28–amino acid neuropeptide, part of the secretin/glucagon family. It is naturally produced in the gut, pancreas, and brain, especially in the hypothalamus and enteric nervous system.

Potential Benefits of VIP (Research-Based)

1. Neuroprotection & Brain Health

• Enhances neuronal survival and protects against excitotoxic damage
• Regulates circadian rhythm and sleep-wake cycles
• May improve memory and cognitive resilience

2. Immune Modulation

• Suppresses excessive inflammation and autoimmunity
• Enhances tolerance and regulatory T-cell activity
• Explored for autoimmune conditions such as RA, IBD, and MS

3. Anti-Inflammatory & Healing

• Protects mucosal barriers (gut, lungs)
• Reduces oxidative stress and tissue injury
• May accelerate wound healing and tissue repair

4. Cardiovascular & Pulmonary Support

• Potent vasodilator → improves circulation and reduces vascular resistance
• Pulmonary benefits: bronchodilation, improved oxygenation
• Studied for pulmonary hypertension and asthma

5. Gastrointestinal Function

• Stimulates intestinal secretion and motility
• Protects gut lining integrity
• Potential applications in IBS, IBD, and leaky gut

Key Caveats

• Short Half-Life: Native VIP degrades quickly; analogs or stabilized formulations are often required.
• Potency: Works at very low concentrations; improper dosing may cause GI upset or hypotension.
• Limited Human Trials: Most clinical use is experimental (except a few orphan-drug studies, e.g., Aviptadil).
• Systemic Effects: Vasodilation and gut motility stimulation may cause flushing, loose stools, or low blood pressure.

Summary:
VIP is a multifunctional neuropeptide that regulates inflammation, immunity, vasodilation, and neuroprotection. Its therapeutic promise spans autoimmunity, pulmonary disease, gut health, and neurodegeneration, though stability and delivery remain key challenges.